Blister Film is a plastic processing technique that involves heating a flat plastic sheet, applying a vacuum to mold a surface, and then cooling the mold before filling it. This technique is widely used in plastic packaging, lighting, advertising, and decoration. However, issues related to the quality of blisters and defects in Pharmaceuticals may arise during the Blister formation process. These types of problems related to blister defects and remedies are explained below.
Distance between two eye marks on foil is not as per drawing.
check the distance between two eye mark.
8. Pinhole detector not working Probable causes:
Probable causes
Suggested Action
Input in PLC is not connected
Connect pinhole detector
Distance between pinhole and rejection system is not proper
Input right distance between pinhole and rejection system
9. Homing not done
Probable causes
Suggested Action
Homing is not performed
Perform homing of all axis
10. Blister Damage in a Sealing station
Probable causes
Suggested Action
PRC setting is not proper
Set the PRC
Improper sealing station knob tightness
Fixed the sealing station
11. Motor overload
Probable causes
Suggested Action
Motor is overheated
-Eliminate the error, wait until the motor has cooled down -Check the mechanical parts for roughness and blockage -Clean the drive unit -Lubricate the moving part
12. Emergency machine stop
Probable causes
Suggested Action
An emergency push-button activated
Unlock the emergency knob by turning it.
13. Blister dropping problem, machine not started after pressing Green button.
Probable causes
Suggested Action
Splice sensor
-Change the number of tracks selected in the PLC after the changeover. -Check the splice sensor, whether it is loose or not -Do the challenge test for PVC sensor and Alu splice
14. Bend Blister or Twisted blister
Probable causes
Suggested Action
Guiding roller before the indexing roller
Use the guiding roller having a diameter of 5mm less than blister width, for example, blister having 110x45mm which is 110mm in length and 45mm in width then, use the guiding roller having a diameter of 40mm. (45mm width-5mm=40mm) to prevent bend blisters.
15. Web direction uneven
Probable causes
Suggested Action
Forming plate
Check the lower forming plate position, tight the lower screw
16. Dott Impression on PVC/PVDC foil after pocket formation
Probable causes
Suggested Action
Heating plate surface
Use the heating tap on the identified surface from which impression generated
17. Web slipping at punching station
Probable causes
Suggested Action
Incomplete forming cavities, wrong blister setting in indexing roller
Remove the web from punching and check causes
Improper pickup
Check pickup assembly for any damaged vacuum pipe, tight their nuts, Check Vaccum.
Misalignment of support plate in punching plate
Align The plate as per blister size
18. Low Air Pressure
Probable causes
Suggested Action
-No compressed air, leakage in the air pressure line -pressure seal defective or set incorrectly -Faulty setting pressure regulator -Wire break in cabling in air pressure controller
Activate the compressed air supply, check the pressure gauge or maintenance unit
19. High-temperature of cooling water
Probable causes
Suggested Action
Thermocouple for cooling water is not connected
Connect the thermocouple, replace the defective one
20. Thermocouple check/ perforation blade
Probable causes
Suggested Action
Actual pressure of thermocouple blade is below 50°C
-Check thermocouple connection -Replace the defective thermocouple -Set the perforation blade temperature above 50°C
Conclusion:
The quality of the blister depends on the material and machine setting as per the given parameters. But sometimes, small problems can lead to harm to the quality of products. So, hope topics related to blister defects and remedies are covered all these problems.
Naresh Bhakar is the Founder and Author at Pharmaguddu.com, bringing his extensive expertise in the field of pharmaceuticals to readers worldwide. He has experience in Pharma manufacturing and has worked with top Pharmaceuticals. He has rich knowledge and provides valuable insights and data through his articles and content on Pharmaguddu.com. For further inquiries or collaborations, please don’t hesitate to reach out via email at [email protected].
