Pharmaguddu

Common Problems and Troubleshooting for Disintegration Test Apparatus

Disintegration test troubleshooting guide showing common USP/Ph. Eur. tablet disintegration apparatus problems, causes, and corrective actions.

Have you ever asked yourself why a tablet, which has passed all the other quality control tests, fails the QC bench? A disintegration test apparatus is used to determine whether a tablet or a capsule disintegrates within a specified time under defined conditions. The test is performed by vertically reciprocating the unit in a liquid maintained at human body temperature. This article describes the working principle of the disintegration test apparatus, its components, the procedure for the disintegration test, calibration, and the disintegration limits set by the manufacturers for different dosage forms. This information will help QC and manufacturing personnel to perform the disintegration test properly and release the batches of the pharmaceutical products.

Common Audit Observations and FDA 483 Findings for Water Systems

Infographic summarizing common FDA 483 audit findings for pharmaceutical water systems, including what causes them, how companies typically respond, and what happens when they don't.

Learn what FDA investigators actually flag most often when auditing pharmaceutical water systems — sampling gaps, sanitization failures, monitoring lapses, validation shortfalls, CAPA deficiencies, and broader GMP compliance issues.

0.1M Perchloric Acid Preparation and Standardization Procedure (IP Method)

Infographic to prepare Crystal Violet Solution with step-by-step procedure, quantity of reagents, adjustment of water content, Karl Fischer testing, storage and quality control points.

Know the step-by-step procedure used to prepare and standardize 0.1M perchloric acid solution as per IP guidelines. Incorporates reagents, equipment, calculation, detection of endpoint, storage of reagents, and standardization with potassium hydrogen phthalate (KHP).

0.004 M Benzethonium Chloride Solution Preparation and Standardization Procedure

Detailed infographic for the preparation, standardization, titration principle and equivalence factor for a pharmaceutical quality control laboratory 0.004 M solution of benzethonium chloride

Preparation and standardization of 0.004 M benzethonium chloride solution with potentiometric titration with 0.1 M perchloric acid. It deals with preparation of reagents, calculation of standardizations, equivalence factor and recommendation on storage for pharmaceutical laboratory applications.

How to Prepare and Standardize 0.05 M Silver Nitrate (SOP)

Infographic showing the preparation, standardization procedure, calculations, and endpoint for 0.05 M silver nitrate solution in pharmaceutical analysis.

Here is the exact process for making and standardizing 0.05 M silver nitrate. Includes the chemicals, the titration procedure and the formula to calculate and storage condition

Preparation and Standardization of 0.025 M Sulphuric Acid Solution

Infographic of preparation and standardization of Sulphuric acid solution 0.025M with anhydrous sodium carbonate showing preparation steps, titration procedure, methyl red indicator, calculation formula and laboratory apparatus.

Know how to prepare 0.025 M sulphuric acid solution using anhydrous sodium carbonate, methyl red indicator, calculations and titration procedure.

How Perform Limit Test for Heavy Metals (SOP)

Complete reagent preparation guide for LIMIT TEST FOR HEAVY METALS ( BP) - steps for preparation of acetate buffer pH 3.5, thioacetamide reagent, lead standard solutions, hydrochloric acid, ammonia, phenolphthalein.

Limit tests for heavy metals need not be confusing. This guide includes detailed protocols with equipment, reagent preparation and step-by-step instructions to perform a typical test procedure. For all of the Test A, B, C and D options, there are clear instructions to ensure your pharmaceutical quality control is accurate and on track. 1.0 Scope: … Read more

How to Perform Solubility Test

Infographic on solubility test procedure and guideline in pharmaceutical quality control; preparation of sample, choice of solvent, dissolution steps, solubility classification table, laboratory apparatus and reagents, and testing conditions.

The solubility test is a basic test performed in the pharmaceutical laboratory to assess the solubility of a substance in a given solvent. This guide describes the entire solubility testing procedure, apparatus used, considerations for selection of solvents, temperature, and standard solubility classification from very soluble to practically insoluble. This step-by-step reference will help you to test accurately and fulfil the pharmaceutical quality requirements.

Capreomycin Sulphate Colour of Solution Test – Complete SOP

Capreomycin Sulphate Colour of Solution Test with sample preparation, reagent standards, Y colour standard, BY colour standard and visual comparison procedure shown in an infographic.

The Capreomycin Sulphate Colour of Solution Test is an important quality control test to check the appearance of a prepared capreomycin solution. This test is performed to ensure the solution meets the pharmacopoeial colour standards, which indicates that the product is of good quality and consistent.

Preparation and Standardization of 0.1M Ethanolic Sodium Hydroxide Solution SOP

Infographic for preparation and standardization of 0.1 M ethanolic sodium hydroxide solution with apparatus, reagents, steps, benzoic acid titration, calculation of molarity, and storage conditions.

This article describes the SOP for preparation and standardization of 0.1M ethanolic sodium hydroxide solution. It includes apparatus, reagents, preparation of the thymolphthalein indicator, preparation of sodium hydroxide solution, standardization procedure of benzoic acid, formula to calculate the molarity, storage conditions and reference as per IP norms. It is a guide for pharmaceutical quality control and analytical laboratories.

List of Pharma Companies in Ahmedabad (Verified 2026)

Pharma companies in Ahmedabad, Gujarat with modern pharmaceutical manufacturing facilities.

As one of the major pharmaceutical manufacturing cities of India, Ahmedabad has multinational companies like Zydus Lifesciences, Torrent Pharmaceuticals, Cadila Pharmaceuticals and Intas Pharmaceuticals. The companies are producers of generics, biosimilars, vaccines, injectables and APIs with the facilities located at Sanand, Moraiya, Changodar and Bavla (PHARMEZ) industrial estates. Working in tandem with the pharmaceutical ecosystem … Read more

SOP for Additional Packing Materials Request using format and ERP

Pharma ERP work order deviated issue request module displaying additional packing material request process, manufacturing transaction management, inventory control, and production workflow in pharmaceutical manufacturing

Download the SOP for Additional Packing Material in pharmaceutical manufacturing. Learn the GMP-compliant procedure for requesting, issuing, approving, and reconciling extra packaging materials

Primary vs Secondary vs Tertiary Packaging: Key Differences with Examples

Pharmaceutical primary packaging materials infographic showing blister packs, bottles, vials, ampoules, pre-filled syringes, and tubes with material composition, packaging type, description, and pharmaceutical product examples.

Learn the differences between primary, secondary, and tertiary pharmaceutical packaging materials with practical examples of bottles, blister packs, cartons, vials, shippers, and pallets used in the pharma industry.

IND Application Explained: FDA Clinical Trial Approval Process Step-by-Step (2026 Guide)

Pharmaceutical researchers reviewing an FDA IND application with clinical trial data, laboratory testing reports, and drug development documentation inside a modern research facility.

IND, or the Investigational New Drug Application, is a U.S. permission process required to move any new medicine or therapy from laboratory research to human testing, meaning clinical trials. For example, imagine scientists have developed a new medicine. They cannot directly test it on humans. First, they must submit proof to the U.S. drug authority through an … Read more

Self-Inspection in Pharma Industry: Importance, Benefits & Internal Audit Process

Quality assurance team performing self inspection and internal audit activities in a pharmaceutical manufacturing production area.

Self-inspection, also known as an internal audit, is a routine check that pharmaceutical companies run on their own to check the gaps between the procedures and documents. All manufacturing and quality teams must follow this process to maintain compliance. We can say it is a review that checks if daily work matches Good Manufacturing Practices … Read more

Laboratory Color Test Procedure: Step-by-Step Guide

Blue SOP file for laboratory color test procedure placed on a stainless steel table in a pharmaceutical QC laboratory

1.0 Scope: Procedure is applicable to perform the colour test of the sample wherever specified. Learn: Procedure to Check Clarity of Sample Solution 2.0 Apparatus:You will need: 3.0 Reagents:Use analytical grade (AR) chemicals for the following: 4.0 Method: A. Ferric Chloride Colorimetric Solution (FCS) Dissolve roughly 55 g of ferric chloride hexahydrate in a mixture … Read more