0.1 M Sodium Nitrite Preparation and Standardization

Preparation and Standardization of 0.1 M Sodium Nitrite (NaNO₂) by using Sulphanilic acid in Pharmaceutical Analysis.

Chemical Name: 0.1 M Sodium Nitrite (NaNO₂)

Reagents:

1.0 Sodium nitrite
2.0 Sulphanilic acid
3.0 Potassium bromide
4.0 2M Hydrochloric Acid
5.0 Starch iodide paper

Preparation of 0.1 M Sodium Nitrite

To make this solution, take 7.5 grams of sodium nitrite and dissolve it in enough distilled water to make 1000 milliliters of the solution.

Standardization of 0.1 M Sodium Nitrite

• To check the strength of the solution, take 0.3 grams of sulphanilic acid and dissolve it in 50 milliliters of 2 M hydrochloric acid.
• Then, add 3 grams of potassium bromide and cool it using ice.
• Now, you can titrate this solution using the sodium nitrite solution and use starch iodide paper to know when it’s ready.
• Each milliliter of 0.1 M sodium nitrite is equal to 0.01732 grams of C₆H₇NO₃S.

Calculation:

Burette Reading (B.R.) is the volume in the burette.

Preparation and Standardization of 0.1 M Sodium Nitrite by using Sulfanilamide in Pharmaceutical Analysis.

Aim: Our goal is to make and measure a 0.1 M sodium nitrite solution using sulfanilamide.

Materials: Glass equipment: Burette, burette stand, flask, pipette, beaker, flask, funnel, glass rod, and a wash bottle.
Chemicals: Sulfanilamide, hydrochloric acid, potassium bromide, and sodium nitrite.

Making of 0.1 M sodium nitrite solution:

Take 7.50 grams of sodium nitrite and dissolve it in 800 milliliters of distilled water. Once it’s fully dissolved, bring the volume up to 1000 milliliters.

Titration process:

• Clean and dry all glassware as per the SOP given.
• Before using the burette, rinse it with distilled water and then with a bit of the solution you’ll use for titration. This makes sure the burette contains the right solution, not something else.
• Fill the burette using a funnel from the unknown stock solution of the titrant.
• Remove air bubbles and set the reading to zero.
• In a 50.00 milliliter solution of 2M hydrochloric acid, dissolve 0.3 grams of sulphanilamide.
• Add 3.00 grams of potassium bromide, cool it on ice, and titrate it with the 0.1 M sodium nitrite solution you prepared until you reach the endpoint, which is determined with a special measurement.
• For accurate results, do the titration three times.
• Make sure to note down the burette readings.
• Find the average of these readings and calculate the strength of the sodium nitrite solution.

Calculations:

1 milliliter of 0.1 M sodium nitrite is equal to 0.01722 grams of sulphanilamide.

Molarity (M) =

Result: The strength of the sodium nitrite solution we prepared was found to be _ M.

Reference: Indian Pharmacopoeia”

FAQs about 0.1 M Sodium Nitrite Solution