Infographic on solubility test procedure and guideline in pharmaceutical quality control; preparation of sample, choice of solvent, dissolution steps, solubility classification table, laboratory apparatus and reagents, and testing conditions.

How to Perform Solubility Test

👤 Written by: Pankaj Sharma
Quality Control Specialist | Industry Experience

✓ Reviewed by: Pankaj Sharma - Quality Control Specialist
Reviewed for Quality Control accuracy, laboratory practices, analytical methods, and technical relevance

📅 Last Updated: June 21, 2026

Understand how to perform the pharmaceutical solubility test, necessary equipment, selection of solvents, classifications of solubility and reporting procedure for the QC lab.

Scope: This procedure is applicable to the solubility test.

Apparatus:

  • Test tube
  • Volumetric flask

Reagents:

As described in the respective specification

Method :

  • Take about 1 g of sample in test tube / volumetric flask (as applicable).
  • Select the solvent as per specification.
  • Based on the solubility of the sample, add the required volume of the particular solvent(s) as per table-I given below.
  • Shake well to dissolve ensuring that the test is carried out at a temperature between 20°C to 30°C.
  • Check sample against the specification for solubility.
Infographic on solubility test procedure and guideline in pharmaceutical quality control; preparation of sample, choice of solvent, dissolution steps, solubility classification table, laboratory apparatus and reagents, and testing conditions.

Table-1

Description termApproximate volume of solvent in milliliters per gram of solute
Very solubleLess than 1
Freely solubleFrom 1 to 10
SolubleFrom 10 to 30
Sparingly solubleFrom 30 to 100
Slightly solubleFrom 100 to 1000
Very slightly solubleFrom 1000 to 10000
Insoluble or practically insolubleMore than 10000

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