In pharmaceutical analysis, a limit test is a type of analytical test used to determine impurity in a substance whether a substance is present in a sample at a concentration above or below a specified limit. Limit tests are often used to ensure that a substance meets certain quality standards or regulatory requirements. Definition The … Read more
Aim: Methyl Orange Indicator Preparation | How to make w/v methyl orange Requirements: Glasswares: Burette, burette stand, conical flask, volumetric pipette, beaker, measuring flask, funnel, glass rod, wash bottle, storage container, etc. Chemicals: Methyl orange, Ethanol 20 ml, and Distilled water. Procedure for Methyl Orange Indicator preparation Related Post: Preparation and Standardization of 0.1 N HCl
To Preparation and Standardization of 0.1 N HCl utilizing sodium carbonate (also comprehended as washing soda, soda ash, and soda crystals) as the primary standard (Acid-base titration). Prerequisites for preparation and standardization of 0.1 N HCL: Glasswares: Burette, stand for burette, a conical flask, volumetric pipette to makeup volume, beaker, volumetric flask, funnel, glass rod, … Read more
Sometimes we may confused when it comes to understanding the difference between moisture content and Loss on Drying (LOD). To clear your doubts, please read the entire section of this post. Firstly, let’s discuss about moisture analyzers. A moisture analyzer is used to determine the water content in a sample. Then a few questions arise … Read more
High-Performance Liquid Chromatography (HPLC) is used in pharmaceuticals for the analysis of drug mixture and their components. HPLC is reverse-phase Liquid Chromatography. This technique is used for thermal labile, high molecular weight peptides, and non-volatile compounds. The main purpose of HPLC is used to examine the mixture for its identification, impurities, and purification. The mixture … Read more
Injectable preparations, also known as parenteral preparations, are sterile formulations used for parenteral infusion or implantation. They are administered by injection to maintain sterility and prevent contamination by foreign matter, pyrogens, microorganisms, and bacterial endotoxins. These preparations must be made using methods that ensure sterility. Water for injection (WFI) is commonly used as a vehicle … Read more
The Friability test helps measure the powder lost from tablet surfaces during handling and transport. This test is typically done on uncoated tablets. The parallel to friability test, tablets hardness, is also tested to know the strength of tablets which is more important for drugs to withstand throw-out their lifecycle. However, hardness is not only a parameter … Read more
Pharmaceutical Sampling involves selecting a portion of a product for a specific purpose. The sample is a part of a material collected following a defined sampling procedure. A Sampling plan specifies the location, the number of units, the quantity of material to collect, and the associated acceptance criteria. The Sampling procedure contains all sampling operations … Read more
MACO and NOEL calculations have great importance in the pharmaceutical industries. NOEL refers to “No observed effect level” and MACO is a “Maximum allowable carryover”. NOEL is used to determine MACO during cleaning validation. NOEL Calculation: NEOL is calculated by using LD50 and average. Adult dose. LD50 is a lethal dose (it may vary), considered an adult’s … Read more
Vernier caliper is used widely in pharmaceutical and other industries for Accurate Measurement of any products and part of the equipment is essential to know the actual dimension. So to measure the dimension first you have to know about, the vernier caliper Definition, procedure, parts, operation, cleaning, error solutions, and purpose. Vernier Caliper Definition: The Dial … Read more
UV-visible spectrophotometer are widely used in the pharmaceutical industry for analyzing and quantifying various drug substances. It is important to ensure that these instruments are calibrated accurately and regularly to obtain reliable and accurate results. In this guide, we will take you through the calibration procedure and parameters of a UV spectrophotometer. Calibration of UV-visible … Read more
Disintegration test apparatus is widely used in pharmaceuticals to identify the disintegration properties of various types of tablets and capsules. The DT apparatus decides whether or not tablets or capsules disintegrate within a recommended time once placed in a liquid medium. What are Disintegration and Principle Disintegration is defined as that state in which no residue of the … Read more